Louis D. Trombetta, Ph.D.
of Pharmacy and Allied Health Professions
Jamaica, NY 11439
Work in my laboratory is concerned with the effects of the dithiocarbamates and metals on the induction of stress
proteins and alterations in cellular antioxidant defense mechanisms. Due to
their range of action the dithiocarbamates have
widespread application in industry, medicine, and agriculture. These compounds
have been reported to produce neuropathological
changes in the areas of the hippocampus and Purkinje cells of the cerebellum.
They have been shown to cause CNS depressant effects characterized by ataxia,
sedation, depression of locomotor activity and
disruption of active and passive avoidance. By the use of electron microscopy,
molecular biology and biochemical techniques my lab studies the effects of
metal/thiocarbamate complexes on the neuronal and astrocytic cytoskeleton. In addition, we examine this
disruption in relation cellular protective mechanisms.