Louis D. Trombetta, Ph.D.


Professor and Chair - Department of Pharmaceutical Scinces

                                     Graduate MS and Ph.D. Programs

St. John's University

College of Pharmacy and Allied Health Professions

Jamaica, NY 11439

Work in my laboratory is concerned with the effects of the dithiocarbamates and metals on the induction of stress proteins and alterations in cellular antioxidant defense mechanisms. Due to their range of action the dithiocarbamates have widespread application in industry, medicine, and agriculture. These compounds have been reported to produce neuropathological changes in the areas of the hippocampus and Purkinje cells of the cerebellum. They have been shown to cause CNS depressant effects characterized by ataxia, sedation, depression of locomotor activity and disruption of active and passive avoidance. By the use of electron microscopy, molecular biology and biochemical techniques my lab studies the effects of metal/thiocarbamate complexes on the neuronal and astrocytic cytoskeleton. In addition, we examine this disruption in relation cellular protective mechanisms.

  Graduate student research

  Publications

  Electron Microscopy Laboratory

  Confocal Laboratory

  Graduate Courses

  Undergraduate Courses

  Micrographs:

 

 

 

email trombetl@stjohns.edu